tert-Butylsulfinamide, (R)-(+)- → HCID 87426830, compound

HRID 623545Notes

Reaction equation

HRID 623545 reaction equation
[F:1][C:2]([F:16])([O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=O)[CH3:14])=[CH:9][CH:8]=1)[CH:3]([F:5])[F:4].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[CH3:17][C:18]([S@:21]([NH:23][CH:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][C:2]([F:16])([F:1])[CH:3]([F:5])[F:4])=[CH:8][CH:9]=1)[CH3:14])=[O:22])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 202028601-[4-(1,1,2,2-Tetrafluoroethoxy)phenyl]ethan-1-one

Product 1

HCID 87426830HCID 87426830, compoundYield 80%

Procedure

The title compound is prepared in 80% yield (0.95 g, a white solid) from 1-(4-(1,1,2,2-tetrafluoroethoxy)phenyl)ethanone (0.82 g, 3.46 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-3524e89a4ff34c61a8afe905c8b8910e
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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