tert-Butylsulfinamide, (R)-(+)- → HCID 87427283, compound

HRID 623549Notes

Reaction equation

HRID 623549 reaction equation
[F:1][C:2]([F:17])([O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=O)[CH3:15])=[CH:10][CH:9]=1)[C:3]([F:6])([F:5])[F:4].[CH3:18][C:19]([S@:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>>[CH3:18][C:19]([S@:22]([NH:24][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([O:7][C:2]([F:17])([F:1])[C:3]([F:6])([F:5])[F:4])=[CH:9][CH:10]=1)[CH3:15])=[O:23])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87333508HCID 87333508, compound

Product 1

HCID 87427283HCID 87427283, compoundYield 78%

Procedure

The title compound is prepared in 78% yield (812 mg, a yellow oil) from 1-(4-(perfluoroethoxy)phenyl)ethanone (737 mg, 2.90 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-4fda948c043c41f4bef12db2eddc8ec9
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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