Cyclopropanecarboxamide → HCID 67508767, compound

HRID 623557Notes

Reaction equation

HRID 623557 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([CH3:12])[N:3]=1.[CH:13]1([C:16]([NH2:18])=[O:17])[CH2:15][CH2:14]1>>[CH:13]1([C:16]([NH:18][C:2]2[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([CH3:12])[N:3]=2)=[O:17])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 80376CyclopropanecarboxamideHCID 2736835Methyl 2-chloro-6-methylpyrimidine-4-carboxylate

Product 1

HCID 67508767HCID 67508767, compoundYield 71%

Procedure

The title compound is prepared in 71% yield (2.70 g, brown oil) from methyl 2-chloro-6-methylpyrimidine-4-carboxylate (3.00 g, 16.1 mmol) and cyclopropanecarboxamide by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record
ord-7d9e98dab295429495381f74106be380
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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