Cyclopropanecarboxamide → HCID 67511557, compound

HRID 623562Notes

Reaction equation

HRID 623562 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:13]1([C:16]([NH2:18])=[O:17])[CH2:15][CH2:14]1>>[CH:13]1([C:16]([NH:18][C:2]2[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=2)[C:5]([O:7][CH3:8])=[O:6])=[O:17])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 80376CyclopropanecarboxamideHCID 2759833Methyl 2-Chloro-6-methylisonicotinate

Product 1

HCID 67511557HCID 67511557, compoundYield 66%

Procedure

The title compound is prepared in 66% yield (1.3 g, a pale yellow solid) from methyl 2-chloro-6-methylisonicotinate (1.5 g, 8.1 mmol) and cyclopropanecarboxamide by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record
ord-17673e2094444d25aa40ba19160f5e67
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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