Acetamide → HCID 67510009, compound

HRID 623563Notes

Reaction equation

HRID 623563 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([CH3:12])[N:3]=1.[C:13]([NH2:16])(=[O:15])[CH3:14]>>[C:13]([NH:16][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([CH3:12])[N:3]=1)(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 178AcetamideHCID 2736835Methyl 2-chloro-6-methylpyrimidine-4-carboxylate

Product 1

HCID 67510009HCID 67510009, compoundYield 68%

Procedure

The title compound is prepared in 68% yield (0.76 g, a yellow solid) from methyl 2-chloro-6-methylpyrimidine-4-carboxylate (1.0 g, 5.4 mmol) and acetamide by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record
ord-b9f80a979b164d81b0d23f6d7f27329c
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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