Propionamide → HCID 67509929, compound

HRID 623564Notes

Reaction equation

HRID 623564 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([CH3:12])[N:3]=1.[C:13]([NH2:17])(=[O:16])[CH2:14][CH3:15]>>[CH3:12][C:4]1[N:3]=[C:2]([NH:17][C:13](=[O:16])[CH2:14][CH3:15])[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=1

Participants

3

Reactant 2

HCID 6578PropionamideHCID 2736835Methyl 2-chloro-6-methylpyrimidine-4-carboxylate

Product 1

HCID 67509929HCID 67509929, compoundYield 61%

Procedure

The title compound is prepared in 61% yield (0.73 g, a yellow solid) from methyl 2-chloro-6-methylpyrimidine-4-carboxylate (1.0 g, 5.4 mmol) and propionamide by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record
ord-8e3178aa035e4d6fb353a4a108ba15a7
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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