Isobutyramide → HCID 67509648, compound

HRID 623565Notes

Reaction equation

HRID 623565 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([CH3:12])[N:3]=1.[C:13]([NH2:18])(=[O:17])[CH:14]([CH3:16])[CH3:15]>>[C:13]([NH:18][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([CH3:12])[N:3]=1)(=[O:17])[CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 68424IsobutyramideHCID 2736835Methyl 2-chloro-6-methylpyrimidine-4-carboxylate

Product 1

HCID 67509648HCID 67509648, compoundYield 88%

Procedure

The title compound is prepared in 88% yield (1.1 g, a yellow solid) from methyl 2-chloro-6-methylpyrimidine-4-carboxylate (1.0 g, 5.4 mmol) and isobutyramide by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record
ord-ff753792d9194fc6abd86fd9df3ae354
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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