Methyl 2-Chloro-6-methylisonicotinate → HCID 67510693, compound

HRID 623571Notes

Reaction equation

HRID 623571 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:13]1([CH2:16][C:17]([NH2:19])=[O:18])[CH2:15][CH2:14]1>>[CH:13]1([CH2:16][C:17]([NH:19][C:2]2[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=2)[C:5]([O:7][CH3:8])=[O:6])=[O:18])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 2759833Methyl 2-Chloro-6-methylisonicotinateHCID 117151662-cyclopropylacetamide

Product 1

HCID 67510693HCID 67510693, compoundYield 67%

Procedure

The title compound is prepared in 67% yield (316 mg) from methyl 2-chloro-6-methylisonicotinate (350 mg, 1.89 mmol) and 2-cyclopropylacetamide (243 mg, 2.45 mmol) by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record
ord-80dfb664aa9a4eee8e2c2f43f745b20f
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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