Propionyl chloride → 2-methoxy-6-propionamido-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:22]=[C:23]([O:25][CH3:26])[N:24]=1)[C:5]([NH:7][CH:8]([C:10]1[CH:11]=[N:12][C:13]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:14][CH:15]=1)[CH3:9])=[O:6].[C:27](Cl)(=[O:30])[CH2:28][CH3:29]>>[CH3:26][O:25][C:23]1[CH:22]=[C:4]([CH:3]=[C:2]([NH:1][C:27](=[O:30])[CH2:28][CH3:29])[N:24]=1)[C:5]([NH:7][CH:8]([C:10]1[CH:11]=[N:12][C:13]([O:16][CH2:17][C:18]([F:19])([F:20])[F:21])=[CH:14][CH:15]=1)[CH3:9])=[O:6]Participants
3
Procedure
The title compound is prepared in 39% yield (11.2 mg) from 2-amino-6-methoxy-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide (25 mg, 0.068 mmol, single enantiomer, Step-1) and propionyl chloride (19 mg, 0.20 mmol) by the similar manner in Step-2 of Example-8.
Sources & evidence
- ORD record
- ord-c94609eba5de476da8080ef74a6d3255
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09302991B2
Reaction notes
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