2-Aminopyrimidine-4-carboxylic acid → 2-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	2-Aminopyrimidine-4-carboxylic acid	HCID 247194	—
Reactant	1-[6-(2,2,2-Trifluoroethoxy)-pyridin-3-yl]-ethylamine hydrochloride	HCID 67509413	—
Product	2-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide	HCID 67511695	80%

Reaction Steps

The title compound is prepared in 80% yield (98 mg, a white solid) from (−)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (92 mg, 0.36 mmol, Amine-1, single enantiomer) and 2-aminopyrimidine-4-carboxylic acid (50 mg, 0.36 mmol) by the similar manner in Step-1 of Example 8.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09302991B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-77a5540a014443c7b3bde41d3e042d44
Source note	uspto-grants-2016_04