HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Aminopyrimidine-4-carboxylic acid → 6-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Aminopyrimidine-4-carboxylic acid | HCID 247328 | — |
| Reactant | 1-[6-(2,2,2-Trifluoroethoxy)-pyridin-3-yl]-ethylamine hydrochloride | HCID 67509413 | — |
| Product | 6-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide | HCID 67510970 | 89% |
Reaction Steps
The title compound is prepared in 89% yield (175 mg, a white solid) from (−)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (148 mg, 0.58 mmol, Amine-1, single enantiomer) and 6-aminopyrimidine-4-carboxylic acid (80 mg, 0.58 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-c4f142f1ee3b4beeb5bc3d72fd3802e3 |
| Source note | uspto-grants-2016_04 |