Propionyl chloride → N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-propionamidopyrimidine-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Propionyl chloride	HCID 62324	—
Reactant	6-amino-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carb oxamide	HCID 67508706	—
Product	N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-propionamidopyrimidine-4-carboxamide	HCID 56966798	—

Reaction Steps

The title compound is prepared from 6-amino-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carb oxamide (30 mg, 0.08 mmol, Step-1, single enantiomer) and propionyl chloride (11 mg, 0.12 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09302991B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-432637f57f8845c9bc038a27d2c24da4
Source note	uspto-grants-2016_04