Propionyl chloride → 2-propionamido-N-(1-(6-(3,3,3-trifluoropropoxy)pyridin-3-yl)ethyl)pyrimidine-4-carb oxamide
Reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:19][CH2:20][CH2:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:18]=2)[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1.[C:26](Cl)(=[O:29])[CH2:27][CH3:28]>>[C:26]([NH:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:19][CH2:20][CH2:21][C:22]([F:24])([F:25])[F:23])=[CH:17][CH:18]=2)[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1)(=[O:29])[CH2:27][CH3:28]Participants
3
Procedure
The title compound is prepared from 2-amino-N-(1-(6-(3,3,3-trifluoropropoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide (Step-1, single enantiomer) and propionyl chloride according to the procedure similar to that described in Step-2 of Example 8.
Sources & evidence
- ORD record
- ord-b61d981ff75e4b5fb2217ace7e586c33
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09302991B2
Reaction notes
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