Cyclobutanecarbonyl chloride → 2-(cyclobutanecarboxamido)-N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylpyrimidine-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Cyclobutanecarbonyl chloride	HCID 78705	—
Reactant	2-amino-N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylpyrimidine-4-carboxamide	HCID 67508615	—
Product	2-(cyclobutanecarboxamido)-N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylpyrimidine-4-carboxamide	HCID 67510043	—

Reaction Steps

The title compound is prepared from 2-amino-N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylpyrimidine-4-carboxamide (20 mg, 0.05 mmol, Step-1, single enantiomer) and cyclobutanecarbonyl chloride (13 mg, 0.1 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09302991B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-921d7c74d20247d3977b69625d1e3230
Source note	uspto-grants-2016_04