HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyrimidine-4-carboxylic acid → 2-amino-N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyrimidine-4-carboxylic acid | HCID 247194 | — |
| Reactant | 1-(5-Fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride | HCID 67509463 | — |
| Product | 2-amino-N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide | HCID 67509937 | 55% |
Reaction Steps
The title compound is prepared in 55% yield (142 mg, a white solid) from (−)-1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (197 mg, 0.72 mmol, Amine-12, single enantiomer) and 2-aminopyrimidine-4-carboxylic acid (100 mg, 0.72 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-31cafb97545449c7be9d62ca583fc9bd |
| Source note | uspto-grants-2016_04 |