Isobutyryl chloride → N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-2-isobutyramidopyrimidine-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Isobutyryl chloride	HCID 62325	—
Reactant	2-amino-N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide	HCID 67509937	—
Product	N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-2-isobutyramidopyrimidine-4-carboxamide	HCID 67508675	—

Reaction Steps

The title compound is prepared from 2-amino-N-(1-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide (20 mg, 0.06 mmol, Step-1, single enantiomer) and isobutyryl chloride (120 mg, 1.1 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09302991B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-69a0868c59c14bc98acd7380c7b97aa9
Source note	uspto-grants-2016_04