Cyclobutanecarbonyl chloride → N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-2-(cyclobutanecarboxamido)pyrimidine-4-carboxamide

Participants

Reaction Steps

The title compound is prepared from 2-amino-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carb oxamide (20 mg, 0.05 mmol, Step-1 of Example 210, single enantiomer) and cyclobutanecarbonyl chloride (32 mg, 0.27 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Provenance & Evidence