HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopicolinic acid → 3-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopicolinic acid | HCID 73836 | — |
| Reactant | 1-[6-(2,2,2-Trifluoroethoxy)-pyridin-3-yl]-ethylamine hydrochloride | HCID 67509413 | — |
| Product | 3-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)picolinamide | HCID 67509770 | 74% |
Reaction Steps
The title compound is prepared in 74% yield (98 mg, a white solid) from (−)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (100 mg, 0.39 mmol, Amine-1, single enantiomer) and 3-aminopicolinic acid (54 mg, 0.39 mmol) by the similar manner in Step-1 of Example-8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-1e2105a334bf4dafb9c06265ff6af43e |
| Source note | uspto-grants-2016_04 |