HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-3-hexen-2-one → 3-(aminomethyl)-4-isopropyl-6-methylpyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-3-hexen-2-one | HCID 5363140 | — |
| Reactant | 3-(Aminomethyl)-6-methyl-4-propylpyridin-2(1H)-oneacetate | HCID 67124140 | — |
| Product | 3-(aminomethyl)-4-isopropyl-6-methylpyridin-2(1H)-one | HCID 67124337 | — |
Reaction Steps
The title compound was prepared in the same manner as described for 3-(aminomethyl)-6-methyl-4-propyl-2(1H)-pyridinone (Intermediate 5) using (3E)-5-methyl-3-hexen-2-one (20 g, 137 mmol). LCMS E-S (M+H)=181.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.8-11.9 (br s, 1H), 7.86-7.96 (br s, 3H), 6.10 (s, 1H), 3.82-3.86 (m, 2H), 3.02-3.09 (m, 1H), 2.17 (s, 3H), 1.08 (d, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446041B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-1c2676f00c524a1ea0e426477301669e |
| Source note | uspto-grants-2016_09 |