HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyrimidine-4-carboxylic acid → (R)-2-amino-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyrimidine-4-carboxylic acid | HCID 247194 | — |
| Reactant | (1R)-1-[3-(trifluoromethyl)phenyl]ethanamine | HCID 2779048 | — |
| Product | (R)-2-amino-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide | HCID 67510410 | 72% |
Reaction Steps
The title compound is prepared in 72% yield (161 mg, a white solid) from (R)-1-(3-(trifluoromethyl)phenyl)ethanamine (136 mg, 0.72 mmol) and 2-aminopyrimidine-4-carboxylic acid (100 mg, 0.72 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-f6129bfa0bbb43d7bbeb95968f719742 |
| Source note | uspto-grants-2016_04 |