Acetyl chloride → HCID 67509024, compound

HRID 623620Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=2)[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1.[C:24](Cl)(=[O:26])[CH3:25]>>[C:24]([NH:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:21])[F:22])[CH:14]=2)[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1)(=[O:26])[CH3:25]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 67508626HCID 67508626, compound

Product 1

HCID 67509024HCID 67509024, compound

Procedure

The title compound is prepared from 2-amino-N-(1-(3-(trifluoromethoxy)phenyl)ethyl)pyrimidine-4-carboxamide (15 mg, 0.05 mmol, Step-1, single enantiomer) and acetyl chloride (4 mg, 0.05 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Sources & evidence

ORD record: ord-4f7db8964c8549aab76341d6dc609049
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302991B2

Reaction notes

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