HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyrimidine-4-carboxylic acid → 2-amino-N-(1-(3-(2,2,2-trifluoroethoxy)phenyl)ethyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyrimidine-4-carboxylic acid | HCID 247194 | — |
| Reactant | 1-[3-(2,2,2-Trifluoro-ethoxy)-phenyl]-ethylamine hydrochloride | HCID 67511007 | — |
| Product | 2-amino-N-(1-(3-(2,2,2-trifluoroethoxy)phenyl)ethyl)pyrimidine-4-carboxamide | HCID 67510853 | 42% |
Reaction Steps
The title compound is prepared in 42% yield (102 mg, a white solid) from 1-(3-(2,2,2-trifluoroethoxy)phenyl)ethanamine hydrochloride (139 mg, 0.72 mmol, Amine-16, single enantiomer) and 2-aminopyrimidine-4-carboxylic acid (100 mg, 0.72 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-c293511f702b4dbf850f025263213b89 |
| Source note | uspto-grants-2016_04 |