Acetyl chloride → 2-acetamido-N-(1-(5-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide
Reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[C:17]([O:19][CH3:20])[CH:18]=2)[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1.[C:27](Cl)(=[O:29])[CH3:28]>>[C:27]([NH:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:21][CH2:22][C:23]([F:25])([F:26])[F:24])=[C:17]([O:19][CH3:20])[CH:18]=2)[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1)(=[O:29])[CH3:28]Participants
3
Procedure
The title compound is prepared from 2-amino-N-(1-(5-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide (15 mg, 0.04 mmol, Step-1, single enantiomer) and acetyl chloride (10 mg, 0.12 mmol) according to the procedure similar to that described in Step-2 of Example 8.
Sources & evidence
- ORD record
- ord-405d4e1df1b94d709222e1861f80bc95
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09302991B2
Reaction notes
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