2-Aminopyrimidine-4-carboxylic acid → HCID 67509723, compound

HRID 623629Notes

Reaction equation

HRID 623629 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH2:15][NH2:16])[CH:6]=[N:7][C:8]=1[O:9][CH2:10][C:11]([F:14])([F:13])[F:12].[NH2:17][C:18]1[N:23]=[C:22]([C:24](O)=[O:25])[CH:21]=[CH:20][N:19]=1>>[NH2:17][C:18]1[N:23]=[C:22]([C:24]([NH:16][CH2:15][C:5]2[CH:6]=[N:7][C:8]([O:9][CH2:10][C:11]([F:12])([F:13])[F:14])=[C:3]([Cl:2])[CH:4]=2)=[O:25])[CH:21]=[CH:20][N:19]=1

Participants

3

Reactant 2

HCID 2471942-Aminopyrimidine-4-carboxylic acidHCID 67509447HCID 67509447, compound

Product 1

HCID 67509723HCID 67509723, compoundYield 17%

Procedure

The title compound is prepared in 17% yield (43 mg, pale yellow oil) from (5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (199 mg, 0.72 mmol, Amine-19) and 2-aminopyrimidine-4-carboxylic acid (100 mg, 0.72 mmol) by the similar manner in Step-1 of Example 8.

Sources & evidence

ORD record
ord-615ae82502364e768043b68fc4e73f68
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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