Acetyl chloride → HCID 67509393, compound

HRID 623630Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][C:15]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[C:16]([Cl:18])[CH:17]=2)=[O:9])[CH:5]=[CH:4][N:3]=1.[C:25](Cl)(=[O:27])[CH3:26]>>[C:25]([NH:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][C:15]([O:19][CH2:20][C:21]([F:23])([F:22])[F:24])=[C:16]([Cl:18])[CH:17]=2)=[O:9])[CH:5]=[CH:4][N:3]=1)(=[O:27])[CH3:26]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 67509723HCID 67509723, compound

Product 1

HCID 67509393HCID 67509393, compound

Procedure

The title compound is prepared from 2-amino-N-((5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide (10 mg, 0.03 mmol, Step-1) and acetyl chloride (7 mg, 0.08 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Sources & evidence

ORD record: ord-56683d093064423aa0848df00890e2f5
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302991B2

Reaction notes

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