Hydrochloric Acid → 2-chloro-6-(hydroxymethyl)-N-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide

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Reaction Steps

To a stirred solution of (6-chloro-4-((1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)pyridin-2-yl)methyl acetate (95 mg, 0.21 mmol, Step-2, single enantiomer) in THF (5 mL) is added 2M aqueous sodium hydroxide solution (0.16 mL, 0.32 mmol) at room temperature, and the mixture is stirred at room temperature for 1 day. The reaction mixture is neutralized with 2M hydrochloric acid (0.16 mL, 0.32 mmol) and extracted with dichloromethane (50 mL×2). The organic layer is washed with brine, dried over sodium sulfate. The organic solvent is removed under reduced pressure to give 72 mg (84% yield) of the title compound as yellow oil.

Provenance & Evidence