2-Aminooxazole → 6-methyl-N-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-2-(oxazol-2-ylamino)pyrimidine-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	2-Aminooxazole	HCID 558521	—
Reactant	2-chloro-6-methyl-N-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide	HCID 87427219	—
Product	6-methyl-N-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-2-(oxazol-2-ylamino)pyrimidine-4-carboxamide	HCID 67510128	—

Reaction Steps

The title compound is prepared from 2-chloro-6-methyl-N-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide (25 mg, 0.06 mmol, Step-1, single enantiomer) and oxazol-2-amine (16 mg, 0.19 mmol) according to the procedure similar to that described in Step-4 of Example 445.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09302991B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-1320aa49b0c74064be576f575d5f6693
Source note	uspto-grants-2016_04