HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride → 2-bromo-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylisonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride | HCID 67509089 | — |
| Reactant | 2-Bromo-6-methylisonicotinic acid | HCID 72211852 | — |
| Product | 2-bromo-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylisonicotinamide | HCID 87426795 | 83% |
Reaction Steps
The title compound is prepared in 83% yield (387 mg, a yellow solid) from (+)-1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (300 mg, 1.0 mmol, Amine-5, single enantiomer) and 2-bromo-6-methylisonicotinic acid (223 mg, 1.0 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-5c0d7103deee44fa8327e5a5e810d39e |
| Source note | uspto-grants-2016_04 |