2-Aminooxazole → N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-2-methyl-6-(oxazol-2-ylamino)isonicotinamide
Reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:23]=[C:24]([CH3:26])[N:25]=1)[C:5]([NH:7][CH:8]([C:10]1[CH:11]=[N:12][C:13]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[C:14]([Cl:16])[CH:15]=1)[CH3:9])=[O:6].[O:27]1[CH:31]=[CH:30][N:29]=[C:28]1[NH2:32]>>[Cl:16][C:14]1[CH:15]=[C:10]([CH:8]([NH:7][C:5](=[O:6])[C:4]2[CH:3]=[C:2]([NH:32][C:28]3[O:27][CH:31]=[CH:30][N:29]=3)[N:25]=[C:24]([CH3:26])[CH:23]=2)[CH3:9])[CH:11]=[N:12][C:13]=1[O:17][CH2:18][C:19]([F:22])([F:21])[F:20]Participants
3
Procedure
The title compound is prepared from 2-bromo-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylisonicotinamide (25 mg, 0.06 mmol, Step-1, single enantiomer) and oxazol-2-amine (16 mg, 0.19 mmol) according to the procedure similar to that described in Step-4 of Example 445.
Sources & evidence
- ORD record
- ord-3acf2d60d52c465a9fb8dfadcc0f8cfc
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09302991B2
Reaction notes
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