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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623644Generated: October 29, 2026

Ethylamine hydrochloride → N4-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-N2-ethyl-6-methylpyridine-2,4-dicarboxamide

https://huagongshe.com/reaction/623644

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthylamine hydrochlorideHCID 11198—
Reactant4-((1-(5-Chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)-6-methylpicolinic acidHCID 67509038—
ProductN4-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-N2-ethyl-6-methylpyridine-2,4-dicarboxamideHCID 67510284—

Reaction Steps

The title compound is prepared from 4-((1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)-6-methylpicolinic acid (15 mg, 0.04 mmol, Step-2, single enantiomer) and ethanamine hydrochloride by the similar manner in Example-2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-e68330ec5c4f428680f1b003e7637744
Source noteuspto-grants-2016_04