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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623645Generated: October 30, 2026

2-(Methoxycarbonyl)-6-methylisonicotinic acid → Methyl 6-methyl-4-((1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)picolinate

https://huagongshe.com/reaction/623645

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Methoxycarbonyl)-6-methylisonicotinic acidHCID 59570879—
Reactant1-(5-Methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochlorideHCID 67509588—
ProductMethyl 6-methyl-4-((1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)picolinateHCID 6750926072%

Reaction Steps

The title compound is prepared in 72% yield (110 mg, clear colorless oil) from 1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (97 mg, 0.36 mmol, Amine-17, single enantiomer) and 2-(methoxycarbonyl)-6-methylisonicotinic acid (70 mg, 0.36 mmol) by the similar manner in Step-1 of Example 8.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-d636837a02994572a1794964fe6f2468
Source noteuspto-grants-2016_04