HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methylpyrimidine-4-carboxylic acid → 2-chloro-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carb oxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methylpyrimidine-4-carboxylic acid | HCID 10535213 | — |
| Reactant | 1-[6-(2,2,2-Trifluoroethoxy)-pyridin-3-yl]-ethylamine hydrochloride | HCID 67509413 | — |
| Product | 2-chloro-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carb oxamide | HCID 87427022 | 74% |
Reaction Steps
The title compound is prepared in 74% yield (480 mg, clear colorless oil) from (−)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (450 mg, 1.7 mmol, Amine-1, single enantiomer) and 2-chloro-6-methylpyrimidine-4-carboxylic acid (300 mg, 1.7 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-efcde459cd1a484fa98311c46a3cdd61 |
| Source note | uspto-grants-2016_04 |