5-Amino-3,4-dimethylisoxazole → 2-((3,4-dimethylisoxazol-5-yl)amino)-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide

HRID 623654Notes

Reaction equation

HRID 623654 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[CH:17][CH:18]=2)[CH3:12])=[O:9])[CH:5]=[C:4]([CH3:25])[N:3]=1.[CH3:26][C:27]1[C:31]([CH3:32])=[C:30]([NH2:33])[O:29][N:28]=1>>[CH3:26][C:27]1[C:31]([CH3:32])=[C:30]([NH:33][C:2]2[N:7]=[C:6]([C:8]([NH:10][CH:11]([C:13]3[CH:14]=[N:15][C:16]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[CH:17][CH:18]=3)[CH3:12])=[O:9])[CH:5]=[C:4]([CH3:25])[N:3]=2)[O:29][N:28]=1

Participants

3

Reactant 2

HCID 883175-Amino-3,4-dimethylisoxazoleHCID 874270222-chloro-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carb oxamide

Product 1

HCID 675088832-((3,4-dimethylisoxazol-5-yl)amino)-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide

Procedure

The title compound is prepared from 2-chloro-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carb oxamide (20 mg, 0.05 mmol, Step-1, single enantiomer) and 3,4-dimethylisoxazol-5-amine (12 mg, 0.1 mmol) according to the procedure similar to that described in Step-4 of Example 445.

Sources & evidence

ORD record
ord-a43458cac23f4f5dafa45b8156f799aa
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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