Nitric Acid → HCID 67985244, compound

Participants

Reaction Conditions

Reaction Steps

HNO3 (1.11 ml, 13.7 mmol) was added to a suspension of 2,4-bis-benzyloxy-1-isopropyl-benzene (3.8 g, 11.44 mmol) in AcOH (46 ml) and the reaction was heated to 70-80° C. for 40 minutes. The solution was cooled down to 0° C. and neutralized with aq. NaHCO3. The organic phase was extracted with AcOEt and the solvent was removed under reduced pressure. The crude reaction mixture was purified by flash chromatography (PE/AcOEt:95/5 to 90/10) and the title compound was obtained as a yellow solid.

Provenance & Evidence