Bromide ion → HCID 57407244, compound

Participants

Reaction Steps

1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-{4-[(2-diethylamino-ethylamino)-methyl]-phenyl}-1H-[1,2,3]triazole-4-carboxylic acid methyl ester N,N-diethylethylenediamine (0.6 mmol) was added at −10° C. to an acetonitrile solution of the bromide adduct obtained in Step A (125 mg, 0.2 mmol), and the reaction mixture was stirred for 30 minutes at this temperature and then warmed up to RT. After completion of the reaction (monitored by TLC), the solvent was removed under reduced pressure and the residue was purified by flash chromatography, the column being previously conditioned with ammonia (DCM/MeOH:80/10). The title compound was obtained as an oil (45%).

Provenance & Evidence