Phosphorus pentachloride → HCID 12937508, compound

Temperature

40 °C

Ethyl 5-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylate (i.e. the product of Step B, 10.0 g, 36.1 mmol) was suspended in anhydrous toluene (300 mL) under a nitrogen atmosphere. Phosphorus pentachloride (8.3 g, 39.8 mmol) was added and the mixture was stirred at 40° C. for 90 min. during which time a clear yellow solution was formed. The reaction was concentrated under reduced pressure to remove most of the toluene. The resulting residue was diluted with diethyl ether (150 mL) and washed with saturated aqueous sodium bicarbonate solution (70 mL) and water (70 mL). The organic layer was dried (MgSO4) and concentrated under reduced pressure to afford the crude product which was recrystallized twice from hexanes (200 mL, 100 mL) to afford the title compound (6.0 g) as a pale yellow solid.

1. customwas formed
2. concentrationThe reaction was concentrated under reduced pressure
3. customto remove most of the toluene
4. additionThe resulting residue was diluted with diethyl ether (150 mL)
5. washwashed with saturated aqueous sodium bicarbonate solution (70 mL) and water (70 mL)
6. dry with materialThe organic layer was dried (MgSO4)
7. concentrationconcentrated under reduced pressure
8. customto afford the crude product which
9. customwas recrystallized twice from hexanes (200 mL, 100 mL)

ORD record

ord-07448cb6a98e4fd6aee6590ea8468de8

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09302999B2