Aluminium lithium hydride → 5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-methanol

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-carboxylate (i.e. the product of Step H, 0.39 g, 0.8 mmol) in anhydrous tetrahydrofuran (6 mL) that was cooled to 0° C. was added a solution of lithium aluminum hydride in tetrahydrofuran (1.0 M, 0.8 mL, 0.8 mmol). The reaction mixture was stirred at 0° C. for 20 min., after which the reaction was quenched with the addition of ethyl acetate (5 mL). The mixture was stirred at 23° C. for 5 min., and then water (6 drops) was added. The mixture was stirred for 5 min., and then sodium sulfate was added. The mixture was stirred for 5 min., and then the mixture was filtered and concentrated under reduced pressure to obtain the title compound (0.35 g, 100%) as a pale yellow oil. The title compound was used directly in the next step without further purification.

Provenance & Evidence