Lithium hydroxide, monohydrate → 1-(3-Chlorobenzyl)-3-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid

Participants

Reaction Steps

To crude ethyl 1-(3-chlorobenzyl)-3-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-2-carboxylate (732 mg, max. 1.57 mmol) in EtOH (2 mL) and H2O (2 mL) was added LiOH.H2O (347 mg, 8.28 mmol). The reaction mixture was stirred at reflux temperature overnight. The reaction mixture was concentrated, diluted with H2O (5 mL) and acidified with aqueous 1 M KHSO4 (10 mL) while cooling with an ice-bath. The precipitate was filtrated, washed with H2O (2×) and dried on filter to give ACI-07 (533 mg, 82% over two steps).

Provenance & Evidence