Hydrochloric Acid → N,3,3-trimethyl-1-butanamine hydrochloride

Participants

Reaction Steps

4 M HCl in dioxane (4.05 mL, 16.2 mmol) was added dropwise to a solution of tert-butyl 3,3-dimethylbutyl(methyl)carbamate (436 mg, 1.62 mmol) in dry dioxane (4 mL) under a N2 atmosphere. The mixture was stirred at room temperature for 3 d. The mixture was evaporated to dryness, co-evaporated with DCM (15 mL) and the residue was stirred in Et2O for 30 min. The solids were filtered off, rinsed with Et2O and dried on air to yield AMN-38 (222 mg, 72%) as a white solid.

Provenance & Evidence