Sodium Hydroxide → HCID 86711841, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-(4-chlorophenyl)-4-methyl-1H-pyrrole-2-carboxylate (11 g, 41.7 mmol) in methanol (140 mL,) and tetrahydrofuran (140 mL) was added sodium hydroxide (140 mL, 6M aqueous solution) and the reaction was stirred at 110° C. for 4 hrs. The reaction mixture was allowed to cool and the organics removed under vacuum. The resulting residue was slurried in water (200 mL) and acidified with acetic acid to pH4. The resulting precipitate was collected by filtration and washed with water to afford the title compound as a grey solid (9.8 g, 99% yield)

Provenance & Evidence