1-Chloro-3-iodobenzene → HCID 86711844, compound

Participants

Reaction Steps

[1-(3-chlorophenyl)-3-(4-chlorophenyl)-4-methyl-pyrrol-2-yl]-(3,3-difluoroazetidin-1-yl)methanone was synthesised according to the procedure described for [3-(4-Chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-pyrrol-2-yl]-(3,3-difluoroazetidin-1-yl)methanone (SC-32) using 1-chloro-3-iodobenzene (1 mL, 8 mmol) and [3-(4-chlorophenyl)-4-methyl-1H-pyrrol-2-yl]-(3,3-difluoroazetidin-1-yl)methanone (200 mg, 0.6 mmol). The product was purified by preparative HPLC (preparative Agilent 1200 Series HPLC system using 30%-95% acetonitrile/water (0.1% Ammonia aq.) over 15 minutes, collecting at 254 nm) to afford the title compound as an off-white solid (223 mg, 89% yield).

Provenance & Evidence