Hydrochloric Acid → HCID 86711847, compound

Participants

Reaction Steps

4 M HCl in dioxane (1.067 mL, 4.27 mmol) was added dropwise to a solution of tert-butyl 2-(1-benzyl-3-(4-chlorophenyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxamido)ethylcarbamate (587 mg, 1.067 mmol) in dry dioxane (5 mL) under a N2 atmosphere. The mixture was stirred at room temperature for 5 d. The mixture was evaporated to dryness and the residue was stirred in Et2O. The solids were filtered off to obtain 400 mg (77%) of the desired product as a white solid.

Provenance & Evidence