Lithium hydroxide, monohydrate → HCID 86711857, compound

Participants

Reaction Steps

A solution of LiOH H2O (214 mg, 5.11 mmol) in H2O (3 mL) was added to a stirred solution of methyl 3-(1-benzyl-3-(4-chlorophenyl)-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxamido)-2,2-dimethylpropanoate (259 mg, 0.511 mmol) in THF (3 mL). The reaction mixture was stirred at room temperature overnight. An extra portion of LiOH H2O (107 mg, 2.55 mmol) was added, followed by the addition of H2O (11 mL) and THF (11 mL). The reaction mixture was stirred at room temperature for 2 d and then acidified with aqueous 0.5 M KHSO4 (10 mL). The product was extracted with DCM (3×20 mL). The organic layers were combined and washed with brine (3×10 mL). The combined organic layers were dried on Na2SO4 and filtered. Solvents were removed in vacuo to give the desired product (233 mg, 93%) as a white foam.

Provenance & Evidence