4-Methylmorpholine → HCID 86672060, compound

Participants

Reaction Conditions

Reaction Steps

In a 500 mL, 3N round-bottomed flask equipped with nitrogen inlet, and a rubber septum, (Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid (25 g, 1.0 eq.) was dissolved in THF (200 mL). The reaction mixture was cooled to 0° C. To this reaction mixture was added Isobutyl chloroformate (24.9 mL, 2.4 eq.) and 4-methylmorpholine (18.5 mL, 2.1 eq.). The reaction mixture was maintained at 0° C. for 1 h. The progress of the reaction was followed by TLC analysis on silica gel with 10% MeOH-dichloromethane as mobile phase. SM Rf=0.20 and Product Rf=0.6. Reaction mixture was filtered through celite bed. The filtrate was used for next step without any work up and purification.

Provenance & Evidence