Hydrazine hydrate (1:1) → HCID 70563549, compound

Participants

Reaction Conditions

Reaction Steps

In a 500-mL, 3N round-bottomed flask equipped with nitrogen inlet, and a rubber septum, (isobutyl carbonic) (Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride was cooled at 0° C. and added hydrazine hydrate (22.32 mL, 5.7 eq.). Reaction mixture was stirred at 0° C. for 1 h. The progress of the reaction was followed by TLC analysis on silica gel with 10% MeOH-dichloromethane as mobile phase. SM Rf=0.6 and Product Rf=0.4. Reaction mixture was filtered through celite bed. Filtrate was poured into ice water (5000 mL) and extracted with EtOAc (3×500 mL). The combined organic layers were washed with brine solution (3×50 mL), dried over MgSO4, filtered, and concentrated by rotary evaporation (25° C., 20 mmHg) to afford 0.920 g of crude compound which was used for next step without further purification.

Provenance & Evidence