Acetone → HCID 58503687, compound

Participants

Reaction Steps

In a 100-mL, 3N round-bottomed flask equipped with Thermometer pocket fitted with water condenser, nitrogen inlet and a rubber septum, 2-chloro-6-methoxypyridine-4-carbothioamide (0.58 g, 1.0 eq.), methyl iodide (0.89 mL, 5.0 eq.) was dissolved in diethyl ether (60 mL) resulting reaction mixture was stir at RT. The progress of the reaction was followed by TLC analysis on silica gel with 20% acetone: hexane as mobile phase which shows that starting material was consumed after 15 h. Precipitate was observed that was collected by filtration on Buchner funnel. Solid was separated and compound was collected by filtration on a Buchner funnel and washed with hexane (100 mL); Yield: 0.257 g (41.44%); LCMS (%): 27.07% [M+H]+ 217.92 RT: 4.216 min. (Crude).

Provenance & Evidence