Methyl iodide → HCID 70558931, compound

HRID 623816Notes

Reaction equation

HRID 623816 reaction equation
[CH:1]([O:4][C:5]1[CH:10]=[C:9]([C:11](=[S:13])[NH2:12])[CH:8]=[C:7]([C:14]([F:17])([F:16])[F:15])[N:6]=1)([CH3:3])[CH3:2].CI.[CH3:20]C(C)=O.CCCCCC>CC(C)=O>[CH:1]([O:4][C:5]1[CH:10]=[C:9]([C:11]([S:13][CH3:20])=[NH:12])[CH:8]=[C:7]([C:14]([F:16])([F:17])[F:15])[N:6]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 21880519Acetone hexaneHCID 88757595HCID 88757595, compound

Product 1

HCID 70558931HCID 70558931, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In a 100 mL capacity 3-neck round-bottomed flask attached with nitrogen bubbler & magnetic stirrer 2-isopropoxy-6-(trifluoromethyl)pyridine-4-carbothioamide (7.5 g), CH3I (10.18 g), dissolved in 75 ml acetone at RT. Reflux it for 2 h. The completion of the reaction was confirmed by TLC with 20% acetone-hexane as mobile phase. The reaction mixture was distilled & crude 2-isopropoxy-6-(trifluoromethyl)pyridine-4-carbimidothioate forwarded to next step.

Workup

  1. temperatureReflux it for 2 h
  2. distillationThe reaction mixture was distilled

Sources & evidence

ORD record
ord-8887ac8deaaf4639b3803aad116ea534
Source dataset
uspto-grants-2016_04
Patent number
US09303000B2

Reaction notes

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