3-Amino-2,6-piperidinedione → 3-(2-methyl-5-nitro-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione

HRID 623840Notes

Reaction equation

HRID 623840 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][C:5](=[O:8])[NH:4][C:3]1=[O:9].[CH3:10][C:11]1[O:12][C:13](=O)[C:14]2[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=1>>[CH3:10][C:11]1[N:1]([CH:2]2[CH2:7][CH2:6][C:5](=[O:8])[NH:4][C:3]2=[O:9])[C:13](=[O:12])[C:14]2[C:15](=[CH:17][CH:18]=[CH:19][C:20]=2[N+:21]([O-:23])=[O:22])[N:16]=1

Participants

3

Reactant 2

HCID 1345083-Amino-2,6-piperidinedione2×HCID 666429832-methyl-5-nitro-4H-benzo[d][1,3]oxazin-4-one

Product 1

HCID 666429823-(2-methyl-5-nitro-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione

Procedure

In certain embodiments, the 3-aminopiperidine-2,6-dione or a salt thereof in step (a) (i.e., reacting 2-methyl-5-nitro-4H-benzo[d][1,3]oxazin-4-one and 3-aminopiperidine-2,6-dione or a salt thereof to form 3-(2-methyl-5-nitro-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione) is free 3-aminopiperidine-2,6-dione. In certain embodiments, the 3-aminopiperidine-2,6-dione or a salt thereof in step (a) is a salt of 3-aminopiperidine-2,6-dione. In certain embodiments, the 3-aminopiperidine-2,6-dione or a salt thereof in step (a) is 3-aminopiperidine-2,6-dione hydrochloride.

Sources & evidence

ORD record
ord-0e1a7366359a4ff79776c06a4d01f42f
Source dataset
uspto-grants-2016_04
Patent number
US09303014B2

Reaction notes

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