HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → Imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Avadomide | HCID 24967599 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Imidazole | HCID 795 | — |
| Product | Diisopropylethylamine | HCID 81531 | — |
Reaction Steps
Reaction of compound 1 with acetyl chloride and base, such as Et3N, Hunig's Base, or imidazole in either acetonitrile or tetrahydrofuran at either room temperature or 45° C. provided compound 1a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303014B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-952d4247feb14436ab3327e47dd645de |
| Source note | uspto-grants-2016_04 |