HRID623879

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID54272639

未命名化合物

结构：Cc1cc(-c2ccc(-c3nc(C(F)(F)F)cn3COCC[Si](C)(C)C)cn2)ccc1O

HCID136378633

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(-c2ccc(-c3nc(C(F)(F)F)cn3COCC[Si](C)(C)C)cn2)ccc1OCC(C)(C)C(=O)OC(C)(C)C

HCID86698168

未命名化合物

收率 34.5%

PROCEDURE

实验过程

By using 2-methyl-4-[5-[4-(trifluoromethyl)-1-(2-trimethylsilylethoxymethyl)-imidazol-2-yl]-2-pyridyl]phenol (224 mg) and tert-butyl 3-hydroxy-2,2-dimethylpropanoate (284 mg), the procedure was carried out in the same manner as in Example 1-1) to obtain tert-butyl 2,2-dimethyl-3-[2-methyl-4-[5-[4-(trifluoromethyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]propanoate (104 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-733a2e2b2ae74c02a65042d2b3562924
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09302996B2
来源说明: uspto-grants-2016_04

反应 SMILES

[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[N:15]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[N:18]=3)=[CH:10][N:9]=2)[CH:5]=[CH:4][C:3]=1[OH:31].O[CH2:33][C:34]([CH3:43])([CH3:42])[C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36]>>[CH3:33][C:34]([CH3:43])([CH2:42][O:31][C:3]1[CH:4]=[CH:5][C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[N:15]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:16]=[C:17]([C:19]([F:20])([F:22])[F:21])[N:18]=3)=[CH:10][N:9]=2)=[CH:7][C:2]=1[CH3:1])[C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36]